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Soy Isoflavones Cinnamon Biotin Vitex. Fructose High glycemic carbs Licorice Coffee Berry. I am Mary Kate Roget. I am not a doctor. If you find an error or omission on this page, I will appreciate document. Consult your doctor before using any treatments.
Many treatments listed here are extremely dangerous. Nothing in the FAQ should be taken as advice. Please use this information only as a starting point for doing more research and for topics to discuss with your doctor.
If your doctor disagrees with these treatments, look up the published studies and show them to her.
If you are interested in a study reference for any statements made in this FAQ, document. Treatment is important because, according to webmd. These women will also develop diabetes at a younger age.
I have a bias. I want to look and feel healthy. I am not so much interested in simply inducing ovulation as I am in weight loss and appearance. This FAQ does not cover fertility issues. Also, I do not have high blood sugar or triglycerides, yet. So, I do not consider treatments that increase insulin secretion to be beneficial for someone like me, even though they may be beneficial for anyone who does have high blood sugar.
This FAQ does not cover surgical options. There is conflicting evidence for some of the features listed above. Everyone will have different features and symptoms. Many women will not have high blood sugar, for example.
That may come in later stages after insulin resistance takes its toll. As one study put it: If you know of other PCOS features not listed above, please document. Despite the name, not all women with PCOS have polycystic ovaries and they are unnecessary for diagnosis. Revised consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome PCOS. J Clin Endocrinol Metab. Definition of polycystic ovary syndrome. Serum free testosterone in polycystic ovary syndrome measured with a new reference method.
The treatment target is basically to reverse the features listed above. Some features are more upstream from others. Low SHBG is probably a consequence of hyperinsulinemia which inhibits its production.
High blood sugar results, over time, from insulin resistance and hyperinsulinemia. But, many are closely interrelated, and there is no consensus as to what exactly is the root cause. High insulin causes high testosterone, and the reverse is also true.
High TNF-alpha causes increased insulin, and the reverse is also true. Most of these features are so tightly related that if you treat one, you are likely to improve all the others.
Lowering lipid levels, improves antioxidant status and decreases inflammation and increases insulin sensitivity. There are many more examples. The one most people know is that if you lower insulin, you lower testosterone, and the reverse is true to a lesser extent. Insulin resistance appears to be the most important feature, but it does not explain everything. The two main targets are androgens and insulin. Most treatments are targeted at blocking androgens and increasing insulin sensitivity.
Increasing insulin sensitivity is good for everyone, and it appears to be especially important for those of us with PCOS. You cannot have too much insulin sensitivity. Insulin sensitivity generally decreases with age and is why the risk of developing Type 2 diabetes increases with age. There is no single treatment that will give you perfect insulin sensitivity. There are many treatments that increase insulin sensitivity somewhat and to varying degrees. One should do as much as possible to try to increase insulin sensitivity and not pin your hopes on any single treatment.
Depression and bipolar disorder are common in PCOS. These neurological symptoms have some features in common with PCOS: There is evidence that treating these features can improve depression, along with PCOS.
There is also evidence that any effective treatment for PCOS will improve depression as well. Doses listed below are per day. Many supplements are better to take in divided doses, 2 or 3 times a day, as many have a short half-life. You may notice that some doses listed here are much higher than the recommended daily value.
If you want any vitamin, drug, herb or nutritional supplement to treat PCOS, you must be aware of the dose required for an effect. At the same time, be aware of doses that may be toxic. If your supermarket multivitamin has 1mg of something, and here is listed mg, it should make you concerned, and you should seek out more information and ask your doctor. However, just because your multivitamin contains something, does not mean that it will have any effect.
Each treatment is given my personal and totally subjective star rating based on 5 stars. I try to base the ratings on the published studies rather than on antidotal evidence. There may be treatments here that get very enthusiastic praise from people, and I only give them three stars or less. It has been noted that several treatments for insulin resistance take more than a month, to several months, to see any benefits. In fact, some treatments, especially those that increase insulin sensitivity may initially, briefly, increase body weight due to anabolic and fat storage effects of insulin.
Keep that in mind if you are judging the effectiveness of any new treatment. Some treatments include references, others were omitted to save space. I have collected over references. Dosages below may be inaccurate. Lifestyle, diet and exercise can be very effective and are often considered the first-line treatment.
Lifestyle changes have been shown to be more effective than Metformin. Of course, you can add other treatments on top of lifestyle for further improvement. Exercise has been shown to increase insulin sensitivity and reduce abdominal fat, blood sugar, and insulin levels.
It is much better to exercise a little every day than a lot every few days. You cannot make up for skipped days and the effect on blood sugar by working out harder the next day. In the study referenced below under Metform, the lifestyle group engaged in physical activity of moderate intensity, such as brisk walking, for at least minutes per week. Cardio training and resistance training each show destinct benefits.
The quote below is from a review article that talks generally about many ways to increase insulin sensitivity. You can read the full article here. Based on available evidence it is likely an optimal program for improving insulin sensitivity might, in addition to an aerobic component like walking, aim even more specifically to selectively deplete body fat while maintaining or building lean tissue by incorporating resistance training.
Manni L, et al. Effect of exercise on ovarian morphology and expression of nerve growth factor and alpha 1 - and beta 2 -adrenergic receptors in rats with steroid-induced polycystic ovaries.
Randeva HS, et al. Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome. Influence of 12 weeks of training by brisk walking on postprandial lipemia and insulinemia in sedentary middle-aged women. Resistive training increases insulin action in postmenopausal women. Effects of aerobic exercise and dietary carbohydrate on energy expenditure and body composition during weight reduction in obese women.
Am J Clin Nutr ; Low glycemic index foods are more slowly absorbed and cause less insulin to be released. Marsh K, et al. The optimal diet for women with polycystic ovary syndrome? Douglas CC, et al.
Role of diet in the treatment of polycystic ovary syndrome. Monounsaturated Fats or polyunsaturated fat should replace Saturated fat For example: Diets high in monounsaturated fats have been shown to increase insulin sensitivity. It will also slow digestion and lower the overall glycemic index of a meal.
High fiber diets increase SHBG which binds to and lowers free testosterone.Low SHBG is probably a consequence of hyperinsulinemia which inhibits its production. It is an excellent antioxidant. There have been no reports of serious adverse events in those taking EPA supplements, even up to 15 grams daily, for prolonged periods of time. More evidence is needed to rate the effectiveness of pyruvate for these uses. I am Mary Kate Calcium pyruvate weight loss plan. Epub May